Postponement is no answer

HDL action on the vascular wall: is the answer NO?

Circulating levels of HDL cholesterol are inversely related to the risk of atherosclerosis, and therapeutic increases in HDL reduce the incidence of cardiovascular events. A new study shows that HDL-associated lysophospholipids stimulate the production of the potent antiatherogenic signaling molecule NO by the vascular endothelium.

Atrial fibrillation: is NO an answer for refractoriness?

The progressive nature of atrial fibrillation (AF) has been attributed to alteration in the electrophysiological properties of the atrial myocardium. As a net effect, a shortening in the refractory period contributes to the substrate, allowing ectopic complex arising and re-entry [1]. Transmembrane ion channel activity determines atrial action potential (AP) shape. Whereas Na and Ca channels ar...

No answer to Alzheimer's disease?

What is the cause of Alzheimer’s disease? What is the treatment? Currently, there is no (clear) answer. But wait, perhaps NO (nitric oxide) is part of the answer. It is known that amyloidpeptides (A ), the major components of amyloid plaque in Alzheimer’s disease, produce endothelial dysfunction in aorta and cerebral blood vessels (Figure).1–4 In addition, cardiovascular risk factors and cerebr...

When No Answer Might Be the Best Answer

Is being left-handed a handicap? The short and useless answer is "yes and no.".

children learning to write. An eminent sinister-handed Dallas plastic surgeon reported: “In parochial summer school the nuns were determined to change me and actually tied my left hand behind my back. The result of this action was tremendous tenacity and endurance! . . . We write left to right and smear our fresh ink across the page.” He added: “Numerous theories throughout history have claimed...